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Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking.
- Source :
-
The journal of medical investigation : JMI [J Med Invest] 2009; Vol. 56 Suppl, pp. 398-400. - Publication Year :
- 2009
-
Abstract
- In the colony of Sprague-Dawley (SD) strain, we found that there were rats expressing a mutant AQP5, which has a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the 3rd transmembrane domain. The mutant molecule scarcely expressed in the acinar cells, probably because of ineffective trafficking. The mutant molecule, however, showed normal water permeability when assessed by the oocyte system.
- Subjects :
- Amino Acid Sequence
Animals
Aquaporin 5 analysis
Biological Transport physiology
Female
Models, Animal
Molecular Sequence Data
Oocytes cytology
Oocytes metabolism
Rats
Rats, Sprague-Dawley
Submandibular Gland metabolism
Xenopus laevis
Aquaporin 5 genetics
Aquaporin 5 physiology
Cell Membrane Permeability physiology
Point Mutation genetics
Water metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1349-6867
- Volume :
- 56 Suppl
- Database :
- MEDLINE
- Journal :
- The journal of medical investigation : JMI
- Publication Type :
- Academic Journal
- Accession number :
- 20224238
- Full Text :
- https://doi.org/10.2152/jmi.56.398