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Cevimeline enhances the excitability of rat superior salivatory neurons.
- Source :
-
The journal of medical investigation : JMI [J Med Invest] 2009; Vol. 56 Suppl, pp. 267-9. - Publication Year :
- 2009
-
Abstract
- Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly stimulates the peripheral mAChRs of the salivary glands. Since cevimeline is distributed in the brain after its oral administration, it is possible that it affects the central nervous system. However, it is unknown how cevimeline affects the superior salivatory (SS) neurons, which control submandibular salivation. In the present study, we examined the effects of cevimeline on the SS neurons using the whole-cell patch-clamp technique in brain slices. In Wistar rats (6-10 days), the SS neurons were retrogradely labeled by Texas Red applied to the chorda-lingual nerve. Two days after injection, whole-cell recordings were obtained from the labeled cells, and miniature excitatory postsynaptic currents (mEPSCs) were examined. Cevimeline induced the inward currents dose-dependently and increased the frequency of mEPSCs. Therefore, it is suggested that cevimeline enhances the excitability via post- and presynaptic muscarinic receptors in the rat SS neurons. In conclusion, cevimeline may enhance the excitability of the SS neurons.
- Subjects :
- Animals
Dose-Response Relationship, Drug
Excitatory Postsynaptic Potentials physiology
Medulla Oblongata cytology
Medulla Oblongata physiology
Models, Animal
Neurons cytology
Neurons physiology
Patch-Clamp Techniques
Rats
Rats, Wistar
Receptors, Muscarinic physiology
Salivation physiology
Submandibular Gland innervation
Submandibular Gland physiology
Excitatory Postsynaptic Potentials drug effects
Medulla Oblongata drug effects
Muscarinic Agonists pharmacology
Neurons drug effects
Quinuclidines pharmacology
Thiophenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1349-6867
- Volume :
- 56 Suppl
- Database :
- MEDLINE
- Journal :
- The journal of medical investigation : JMI
- Publication Type :
- Academic Journal
- Accession number :
- 20224198
- Full Text :
- https://doi.org/10.2152/jmi.56.267