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Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke.
- Source :
-
Neurological research [Neurol Res] 2010 Sep; Vol. 32 (7), pp. 743-7. Date of Electronic Publication: 2010 Mar 10. - Publication Year :
- 2010
-
Abstract
- Objective: We investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke.<br />Methods: The subjects were 105 consecutive patients without diabetes who were hospitalized due to non-cardioembolic stroke. The insulin resistance was evaluated by a homeostasis model assessment of insulin resistance (HOMA-IR). The degrees of periventricular hyperintensity (PVH) and deep and subcortical white matter hyperintensity (DSWMH) were evaluated by the brain MRI. The HOMA-IR values >or=2.5 were indicative of the insulin resistance.<br />Results: The presence of PVH and DSWMH were 86.7 and 83.8%, respectively. The ratio of insulin resistance increased with higher grades of PVH and DSWMH. The HOMA-IR level in grade 3 PVH was significantly higher than those in grades 0 and 1. The HOMA-IR level in grade 3 DSWMH was significantly higher than those in grades 0-2. Multiple linear regression analysis showed that HOMA-IR was significantly associated with PVH or DSWMH.<br />Conclusion: It was found that insulin resistance correlated with white matter lesions among non-diabetic patients with non-cardiogenic ischemic stroke.
Details
- Language :
- English
- ISSN :
- 1743-1328
- Volume :
- 32
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Neurological research
- Publication Type :
- Academic Journal
- Accession number :
- 20223079
- Full Text :
- https://doi.org/10.1179/016164109X12608733393755