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Fetal genotyping for platelets antigens: a precise tool for alloimmune thrombocytopenia: case report and literature review.
- Source :
-
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2010 Nov; Vol. 282 (5), pp. 573-5. Date of Electronic Publication: 2010 Mar 09. - Publication Year :
- 2010
-
Abstract
- Introduction: Maternal-fetal alloimmune thrombocytopenia complicates about 0.1% of all pregnancies and is associated with major fetal and neonatal morbidity and mortality, especially spontaneous central nervous system bleeding leading to death and neurological handicaps. Successful prevention and treatment depend on the identification of at-risk possible carriers of anti-platelet antibodies.<br />Case Report: We report a case of a mother with a previous child that developed neonatal hemorrhage; HPA-5b anti-platelet antibodies were detected post-natally. During the next pregnancy, fetal genotyping confirmed the presence of HPA-5b antigen; she was treated with weekly intravenous human immunoglobulin and oral prednisone. Pregnancy evolved without remarkable features and a full-term baby was delivered, with normal platelet counts.<br />Conclusion: Fetal alloimmune thrombocytopenia is a potentially lethal condition, but early detection and prevention lead to successful outcome in most cases.
- Subjects :
- Antigens, Human Platelet genetics
Female
Humans
Immunoglobulins, Intravenous administration & dosage
Infant, Newborn
Male
Prednisone administration & dosage
Pregnancy
Thrombocytopenia diagnostic imaging
Thrombocytopenia genetics
Thrombocytopenia prevention & control
Ultrasonography, Prenatal
Antigens, Human Platelet immunology
Isoantigens immunology
Thrombocytopenia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0711
- Volume :
- 282
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of gynecology and obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 20217108
- Full Text :
- https://doi.org/10.1007/s00404-010-1415-3