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Diurnal differences in memory and learning in young and adult rats treated with methylphenidate.
- Source :
-
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2010 Apr; Vol. 117 (4), pp. 457-62. Date of Electronic Publication: 2010 Mar 06. - Publication Year :
- 2010
-
Abstract
- Methylphenidate (MPH) is a very effective treatment option for children and adolescents with attention-deficit/hyperactivity disorder. Nevertheless, there have been inconsistent reports regarding the effects of MPH on learning and memory. The aim of this study was to evaluate whether the treatment with MPH during the morning differs from that during the night on learning and memory (short and long term) in young and adult male Wistar rats. The animals received once daily intraperitoneal injection of either MPH (2 mg/kg) or saline (0.9%) for 28 days (either in the morning or at night). The animals underwent two behavioral tasks to evaluate learning and memory: inhibitory avoidance task and continuous multiple trials step-down inhibitory avoidance (CMIA). Young rats treated in the morning showed significant impaired long-term memory for inhibitory avoidance training and facilitated acquisition in the CMIA. Adult rats treated in the night showed impaired long-term retention in the CMIA. We observed similar performances in both tests for young rats treated at night or adult rats treated in the morning. Our results suggest that age and time of treatment can alter the MPH effects in learning and memory.
- Subjects :
- Animals
Avoidance Learning physiology
Injections, Intraperitoneal
Male
Memory physiology
Memory, Short-Term drug effects
Memory, Short-Term physiology
Neuropsychological Tests
Rats
Rats, Wistar
Time Factors
Aging
Avoidance Learning drug effects
Memory drug effects
Methylphenidate administration & dosage
Nootropic Agents administration & dosage
Photoperiod
Subjects
Details
- Language :
- English
- ISSN :
- 1435-1463
- Volume :
- 117
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission (Vienna, Austria : 1996)
- Publication Type :
- Academic Journal
- Accession number :
- 20213427
- Full Text :
- https://doi.org/10.1007/s00702-010-0385-8