Back to Search Start Over

[The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats].

Authors :
Chalisova NI
Lesniak VV
Balykina NA
Urt'eva SA
Urt'eva TA
Sukhonos IuA
Zhekalov AN
Source :
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2009; Vol. 22 (3), pp. 409-13.
Publication Year :
2009

Abstract

The effect of 20 amino acids and the synthetic tetrapeptide cardiogen in concentration 10(-12) M was investigated in organotypic tissue culture on the cell proliferation and apoptosis development in myocard tissue explant in 3- and 24-months old rats. 7 of 20 amino acids stimulated the cell proliferation in the young rats. In the same time, only 2 amino acids were active in myocard culture from the old rats. The tetrapeptide cardiogen demonstrated the great stimulating effect on the proliferation both in tissues from young and old rats. The immunohistochemical study demonstrated a decrease of the p53 protein expression by cardiogen action. This fact can testify that cardiogen inhibits the apoptosis process in the myocard tissue.

Details

Language :
Russian
ISSN :
1561-9125
Volume :
22
Issue :
3
Database :
MEDLINE
Journal :
Advances in gerontology = Uspekhi gerontologii
Publication Type :
Academic Journal
Accession number :
20210190