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Vitamin D controls T cell antigen receptor signaling and activation of human T cells.
Vitamin D controls T cell antigen receptor signaling and activation of human T cells.
- Source :
-
Nature immunology [Nat Immunol] 2010 Apr; Vol. 11 (4), pp. 344-9. Date of Electronic Publication: 2010 Mar 07. - Publication Year :
- 2010
-
Abstract
- Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.
- Subjects :
- Cells, Cultured
Enzyme Activation immunology
Humans
Immunoblotting
In Situ Hybridization
Phospholipase C gamma biosynthesis
Phospholipase C gamma immunology
Receptors, Calcitriol immunology
Lymphocyte Activation immunology
Receptors, Antigen, T-Cell immunology
Signal Transduction immunology
Vitamin D immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 11
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20208539
- Full Text :
- https://doi.org/10.1038/ni.1851