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Vitamin D controls T cell antigen receptor signaling and activation of human T cells.

Vitamin D controls T cell antigen receptor signaling and activation of human T cells.

Authors :
von Essen MR
Kongsbak M
Schjerling P
Olgaard K
Odum N
Geisler C
Source :
Nature immunology [Nat Immunol] 2010 Apr; Vol. 11 (4), pp. 344-9. Date of Electronic Publication: 2010 Mar 07.
Publication Year :
2010

Abstract

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.

Details

Language :
English
ISSN :
1529-2916
Volume :
11
Issue :
4
Database :
MEDLINE
Journal :
Nature immunology
Publication Type :
Academic Journal
Accession number :
20208539
Full Text :
https://doi.org/10.1038/ni.1851