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Flow cytometry vs cytomorphology for the detection of hematologic malignancy in body cavity fluids.
- Source :
-
Leukemia research [Leuk Res] 2010 Aug; Vol. 34 (8), pp. 1027-34. Date of Electronic Publication: 2010 Mar 05. - Publication Year :
- 2010
-
Abstract
- Flow cytometry and cytomorphology results on 92 body cavity fluids [61 effusions and 31 bronchoalveolar lavage fluids (BALF)] from hematologic malignancy were compared with retrospective clinical outcome. We observed double true positive/negative results in 67 cases (73%), and double false negative results in 2 cases (2%). Immunophenotyping accounted for true positive/negative results in 22 out of 23 mismatched cases (25%), and retained significantly higher accuracy than that of cytomorphology especially in effusions and differentiated lymphoma. In BALF analysis, immunophenotyping and cytomorphology sensitivity was 75% and 0%, respectively. Flow cytometry retains the highest accuracy in detecting neoplastic cells in body cavity fluids.<br /> (Copyright (c) 2010 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-5835
- Volume :
- 34
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Leukemia research
- Publication Type :
- Academic Journal
- Accession number :
- 20206995
- Full Text :
- https://doi.org/10.1016/j.leukres.2010.02.008