Back to Search
Start Over
[Dopaminergic stimulation in the non-motor symptoms of Parkinson's disease].
- Source :
-
Revista de neurologia [Rev Neurol] 2010 Feb 08; Vol. 50 Suppl 2, pp. S85-94. - Publication Year :
- 2010
-
Abstract
- Introduction and Development: The non-motor symptoms of Parkinson's disease have a great impact in terms of quality of life. They are frequently underdiagnosed and clinical experience suggests that not only is dopamine therapy ineffective but that in many cases it is also responsible for the appearance of some of these symptoms. Different studies have drawn attention to the involvement of the dopaminergic pathways in the pathogenesis of some non-motor symptoms. It has been observed that they can undergo fluctuations in relation to dopaminergic stimulation, generally in wearing off states, while displaying a significant correlation with motor fluctuations and a clinical response with continuous dopaminergic therapy.<br />Conclusions: Although recent reviews offer insufficient evidence for treatment of non-motor symptoms with dopaminergic therapy, involvement of the dopaminergic pathways in the aetiopathogenesis of some of these disorders and the clinical observation that such symptoms undergo fluctuations in relation to pulsatile dopaminergic stimulation may lead us to reconsider the possible role of dopaminergic therapy in the treatment of these symptoms.
- Subjects :
- Autonomic Nervous System Diseases drug therapy
Autonomic Nervous System Diseases etiology
Autonomic Nervous System Diseases physiopathology
Digestive System Diseases drug therapy
Digestive System Diseases etiology
Digestive System Diseases physiopathology
Disorders of Excessive Somnolence drug therapy
Disorders of Excessive Somnolence etiology
Disorders of Excessive Somnolence physiopathology
Humans
Levodopa therapeutic use
Mental Disorders drug therapy
Mental Disorders etiology
Mental Disorders physiopathology
Parkinson Disease complications
Parkinson Disease physiopathology
REM Sleep Parasomnias drug therapy
REM Sleep Parasomnias etiology
REM Sleep Parasomnias physiopathology
Sexual Dysfunction, Physiological drug therapy
Sexual Dysfunction, Physiological etiology
Sexual Dysfunction, Physiological physiopathology
Sleep Apnea Syndromes drug therapy
Sleep Apnea Syndromes etiology
Sleep Apnea Syndromes physiopathology
Urologic Diseases drug therapy
Urologic Diseases etiology
Urologic Diseases physiopathology
Dopamine Agonists therapeutic use
Parkinson Disease drug therapy
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1576-6578
- Volume :
- 50 Suppl 2
- Database :
- MEDLINE
- Journal :
- Revista de neurologia
- Publication Type :
- Academic Journal
- Accession number :
- 20205148