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RTEL-1 enforces meiotic crossover interference and homeostasis.
- Source :
-
Science (New York, N.Y.) [Science] 2010 Mar 05; Vol. 327 (5970), pp. 1254-8. - Publication Year :
- 2010
-
Abstract
- Meiotic crossovers (COs) are tightly regulated to ensure that COs on the same chromosome are distributed far apart (crossover interference, COI) and that at least one CO is formed per homolog pair (CO homeostasis). CO formation is controlled in part during meiotic double-strand break (DSB) creation in Caenorhabditis elegans, but a second level of control must also exist because meiotic DSBs outnumber COs. We show that the antirecombinase RTEL-1 is required to prevent excess meiotic COs, probably by promoting meiotic synthesis-dependent strand annealing. Two distinct classes of meiotic COs are increased in rtel-1 mutants, and COI and homeostasis are compromised. We propose that RTEL-1 implements the second level of CO control by promoting noncrossovers.
- Subjects :
- Animals
Caenorhabditis elegans physiology
Caenorhabditis elegans Proteins genetics
Chromatids genetics
Chromosomal Proteins, Non-Histone genetics
Chromosomal Proteins, Non-Histone metabolism
DNA Breaks, Double-Stranded
DNA Helicases genetics
DNA Repair
DNA, Helminth genetics
DNA, Helminth metabolism
Homeostasis
Mutation
Polymorphism, Single Nucleotide
X Chromosome genetics
Caenorhabditis elegans genetics
Caenorhabditis elegans Proteins metabolism
Crossing Over, Genetic
DNA Helicases metabolism
Meiosis
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 327
- Issue :
- 5970
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 20203049
- Full Text :
- https://doi.org/10.1126/science.1183112