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The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 01; Vol. 20 (7), pp. 2340-3. Date of Electronic Publication: 2010 Feb 04. - Publication Year :
- 2010
-
Abstract
- The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure-activity relationships and the process of optimisation of an initial HTS hit are also described.<br /> (2010 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20202837
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.01.133