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Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.
- Source :
-
Applied and environmental microbiology [Appl Environ Microbiol] 2010 May; Vol. 76 (9), pp. 3039-43. Date of Electronic Publication: 2010 Feb 26. - Publication Year :
- 2010
-
Abstract
- A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator.
Details
- Language :
- English
- ISSN :
- 1098-5336
- Volume :
- 76
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Applied and environmental microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 20190084
- Full Text :
- https://doi.org/10.1128/AEM.02426-09