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[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency].
- Source :
-
Medecine sciences : M/S [Med Sci (Paris)] 2010 Feb; Vol. 26 (2), pp. 159-63. - Publication Year :
- 2010
-
Abstract
- The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.
- Subjects :
- DNA, Viral genetics
Epigenesis, Genetic
Gene Expression Regulation, Viral
HIV Infections virology
HIV-1 genetics
Host-Pathogen Interactions
Humans
Microglia virology
Proviruses genetics
Proviruses physiology
RNA, Viral genetics
Transcription, Genetic
Virus Integration
Virus Latency genetics
HIV-1 physiology
Virus Latency physiology
Subjects
Details
- Language :
- French
- ISSN :
- 0767-0974
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Medecine sciences : M/S
- Publication Type :
- Academic Journal
- Accession number :
- 20188047
- Full Text :
- https://doi.org/10.1051/medsci/2010262159