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3-Substituted pyrazinone nucleosides--a new family of D4T analogues.
- Source :
-
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2009 Sep; Vol. 28 (9), pp. 866-73. - Publication Year :
- 2009
-
Abstract
- The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
Details
- Language :
- English
- ISSN :
- 1532-2335
- Volume :
- 28
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nucleosides, nucleotides & nucleic acids
- Publication Type :
- Academic Journal
- Accession number :
- 20183624
- Full Text :
- https://doi.org/10.1080/15257770903169999