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Mechanisms of platelet recovery in ITP associated with therapy.
- Source :
-
Annals of hematology [Ann Hematol] 2010 Jul; Vol. 89 Suppl 1, pp. 31-5. Date of Electronic Publication: 2010 Feb 24. - Publication Year :
- 2010
-
Abstract
- Immune thrombocytopenia (ITP) is an autoimmune disease primarily characterized by increased clearance of auto-antibody-sensitized platelets by Fc-receptor-bearing macrophages in the spleen and liver. It has been classically accepted that antibody-mediated platelet destruction is Fc dependent. Recent studies, however, may also indicate the involvement of Fc-independent pathways of platelet destruction. Current treatment options work by immunosuppression (e.g., corticosteroids), immunomodulation (e.g., IVIg and anti-D), or removal of the platelet destruction site (splenectomy) in ITP. This review will discuss the mechanisms of action of these and other treatments for ITP.
- Subjects :
- Antigens, Human Platelet immunology
Autoantibodies
Humans
Immunomodulation
Recovery of Function
Spleen immunology
Treatment Outcome
Adrenal Cortex Hormones therapeutic use
Immunoglobulins, Intravenous therapeutic use
Immunosuppressive Agents therapeutic use
Purpura, Thrombocytopenic, Idiopathic immunology
Purpura, Thrombocytopenic, Idiopathic therapy
Receptors, Fc immunology
Splenectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0584
- Volume :
- 89 Suppl 1
- Database :
- MEDLINE
- Journal :
- Annals of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 20179926
- Full Text :
- https://doi.org/10.1007/s00277-010-0916-2