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On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes.
- Source :
-
Development (Cambridge, England) [Development] 2010 Mar; Vol. 137 (6), pp. 845-57. - Publication Year :
- 2010
-
Abstract
- The regulation of body axis specification in the common ancestor of bilaterians remains controversial. BMP signaling appears to be an ancient program for patterning the secondary, or dorsoventral, body axis, but any such program for the primary, or anteroposterior, body axis is debated. Recent work in invertebrates indicates that posterior Wnt/beta-catenin signaling is such a mechanism and that it evolutionarily predates the cnidarian-bilaterian split. Here, I argue that a Cartesian coordinate system of positional information set up by gradients of perpendicular Wnt and BMP signaling is conserved in bilaterians, orchestrates body axis patterning and contributes to both the relative invariance and diversity of body forms.
- Subjects :
- Animals
Bone Morphogenetic Proteins metabolism
Chordata, Nonvertebrate anatomy & histology
Chordata, Nonvertebrate embryology
Chordata, Nonvertebrate genetics
Chordata, Nonvertebrate physiology
Cnidaria anatomy & histology
Cnidaria embryology
Cnidaria genetics
Cnidaria physiology
Embryo, Nonmammalian
Evolution, Molecular
Gene Expression Regulation, Developmental
Models, Biological
Models, Theoretical
Phylogeny
Signal Transduction physiology
Wnt Proteins metabolism
Body Patterning physiology
Bone Morphogenetic Proteins physiology
Growth and Development physiology
Wnt Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9129
- Volume :
- 137
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Development (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 20179091
- Full Text :
- https://doi.org/10.1242/dev.039651