A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation.

Authors :: Stanley CE
Elvira KS
Niu XZ
Gee AD
Ces O
Edel JB
Demello AJ
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Mar 14; Vol. 46 (10), pp. 1620-2. Date of Electronic Publication: 2010 Jan 25.
Publication Year :: 2010
Abstract: We present a simple, automated method for high-throughput formation of droplet interface bilayers (DIBs) in a microfluidic device. We can form complex DIB networks that are able to fill predefined three dimensional architectures. Moreover, we demonstrate the flexibility of the system by using a variety of lipids including 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

Subjects :: Fluorescein chemistry
Oils chemistry
Phosphatidylcholines chemistry
Water chemistry
Lipid Bilayers chemistry
Microfluidic Analytical Techniques instrumentation
Microfluidic Analytical Techniques methods

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