Back to Search
Start Over
Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?
- Source :
-
Molecular nutrition & food research [Mol Nutr Food Res] 2010 May; Vol. 54 (5), pp. 661-8. - Publication Year :
- 2010
-
Abstract
- There is growing concern based on meta-analyses of clinical trials using vitamin E supplements that these supplements increase the risk of all-cause mortality in humans. My laboratory has been investigating the metabolism and disposition of "excess" vitamin E. This review focuses on the various mechanisms that prevent vitamin E intoxication. Non-alpha-tocopherols are aggressively metabolized thereby preventing their tissue accumulation and limiting increases in their plasma concentrations. Moreover, "excess" alpha-tocopherol is also metabolized and its concentrations are limited. The mechanisms for this limitation do not seem to be specific for vitamin E, but rather are general xenobiotic pathways. We suggest that the most relevant cytochrome P450-mediated pathway is the one that is most important for the regulation and activation of vitamin K, specifically the one dependent on CYP4F2.
- Subjects :
- Cytochrome P-450 CYP3A metabolism
Cytochrome P-450 Enzyme System metabolism
Cytochrome P450 Family 4
Homeostasis
Humans
Liver enzymology
Liver metabolism
Pregnane X Receptor
Receptors, Steroid metabolism
Signal Transduction physiology
Vitamin E therapeutic use
Vitamin E toxicity
Vitamin K metabolism
gamma-Tocopherol metabolism
Xenobiotics metabolism
alpha-Tocopherol metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1613-4133
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecular nutrition & food research
- Publication Type :
- Academic Journal
- Accession number :
- 20169584
- Full Text :
- https://doi.org/10.1002/mnfr.200900440