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Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Mar 15; Vol. 20 (6), pp. 1985-9. Date of Electronic Publication: 2010 Jan 25. - Publication Year :
- 2010
-
Abstract
- From an HTS hit, a series of potent and selective inhibitors of GSK3beta have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Drug Design
Glycogen Synthase Kinase 3 beta
Models, Molecular
Substrate Specificity
CDC2 Protein Kinase antagonists & inhibitors
Cyclin-Dependent Kinase 2 antagonists & inhibitors
Glycogen Synthase Kinase 3 antagonists & inhibitors
Protein Kinase Inhibitors chemistry
Protein Kinase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20167481
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.01.114