Tissue distribution of tetrodotoxin in the red-spotted newt Notophthalmus viridescens.

Authors :: Mebs D
Arakawa O
Yotsu-Yamashita M
Source :: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2010 Jun 15; Vol. 55 (7), pp. 1353-7. Date of Electronic Publication: 2010 Feb 16.
Publication Year :: 2010
Abstract: High levels of tetrodotoxin (TTX) and of its analogue 6-epi-tetrodotoxin have been detected in skin and liver extracts of the red-spotted newt Notophthalmus viridescens assayed by a post-column fluorescent-HPLC system. Using a monoclonal antibody-based immunoenzymatic technique, TTX was localized in the granular glands of the epidermis as well as in the muscle layer between the muscle fibres, but also in most organs suggesting that TTX is stored in the whole body of the newt and is secreted by skin glands.<br /> (2010 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Chromatography, High Pressure Liquid
Exocrine Glands metabolism
Immunohistochemistry
Liver metabolism
Muscle, Skeletal metabolism
Notophthalmus viridescens
Skin metabolism
Spectrometry, Fluorescence
Tetrodotoxin analogs & derivatives
Tissue Distribution
Tetrodotoxin pharmacokinetics

Language :: English
ISSN :: 1879-3150
Volume :: 55
Issue :: 7
Database :: MEDLINE
Journal :: Toxicon : official journal of the International Society on Toxinology
Publication Type :: Academic Journal
Accession number :: 20167230
Full Text :: https://doi.org/10.1016/j.toxicon.2010.02.009

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