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Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2010; Vol. 20 (2), pp. 417-21. - Publication Year :
- 2010
-
Abstract
- A recent paper reported that a variant (rs2986017) of the calcium homeostasis modulator 1 (CALHM1) gene affects risk for late-onset Alzheimer's disease (AD). This study aims to investigate whether single nucleotide polymorphisms (SNPs) of the CALHM1 gene are associated with AD. SNPs in the genes of two other CALHM subtypes, CALHM2 and CALHM3, were also studied. Our study failed to detect any association between the SNPs of the three genes and AD. Although rs729211 showed marginal association in the APOE4 negative group, the linkage disequilibrium analysis results suggest this to be a false positive.
- Subjects :
- Aged
Apolipoprotein E4 genetics
Calcium Channels genetics
Female
Gene Frequency
Genome-Wide Association Study methods
Genotype
Humans
Japan
Linkage Disequilibrium physiology
Male
Membrane Glycoproteins classification
Middle Aged
Regression Analysis
Alzheimer Disease ethnology
Alzheimer Disease genetics
Genetic Predisposition to Disease
Membrane Glycoproteins genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 20164573
- Full Text :
- https://doi.org/10.3233/JAD-2010-1380