Back to Search
Start Over
TFE3 expression in tumors of the microphthalmia-associated transcription factor (MiTF) family.
- Source :
-
International journal of surgical pathology [Int J Surg Pathol] 2011 Feb; Vol. 19 (1), pp. 26-30. Date of Electronic Publication: 2010 Feb 16. - Publication Year :
- 2011
-
Abstract
- The DNA-binding factor TFE3 is closely related to microphthalmia-associated transcription factor (MiTF) and is over-expressed in alveolar soft part sarcoma (ASPS) and select renal cell carcinomas. Reports of TFE3 expression in PEComa prompted investigation into TFE3 expression among other members of the putative MiTF group of neoplasms. The authors examined cases of PEComa (n = 6), conventional angiomyolipoma (AML; n = 22), metastatic melanoma (n = 16), and clear cell sarcoma (CCS; n = 9) for TFE3 expression. Nuclear immunostaining was observed in 74% (39/53) of cases, as follows: 5/6 PEComas, 18/22 AMLs, 10/16 metastatic melanomas, and 6/9 CCSs. However, with the exception of PEComas, compared with ASPS controls, TFE3 staining was significantly less intense in the tumors examined. These results illustrate that TFE3 immunoreactivity is detectable in other members of the MiTF family of neoplasms. For this reason, such neoplasms warrant consideration in the differential diagnosis with nuclear TFE3 immunoreactivity, particularly when staining is focal and less intense.
- Subjects :
- Cell Nucleus metabolism
Humans
Immunohistochemistry
Retrospective Studies
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors metabolism
Carcinoma, Renal Cell metabolism
Kidney Neoplasms metabolism
Liver Neoplasms metabolism
Melanoma metabolism
Microphthalmia-Associated Transcription Factor metabolism
Perivascular Epithelioid Cell Neoplasms metabolism
Sarcoma, Alveolar Soft Part metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1940-2465
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 20164056
- Full Text :
- https://doi.org/10.1177/1066896909352861