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A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2009 Dec; Vol. 32 (12), pp. 1695-8. Date of Electronic Publication: 2010 Feb 17. - Publication Year :
- 2009
-
Abstract
- One new C(29) sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC(50) in the range of 12.8-27.8 microM.
- Subjects :
- Animals
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Proliferation drug effects
Chromatography, Ion Exchange
Chromatography, Thin Layer
Coloring Agents
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
Molecular Conformation
Spectrophotometry, Infrared
Sterols isolation & purification
Sterols pharmacology
Tetrazolium Salts
Thiazoles
Vietnam
Antineoplastic Agents chemistry
Porifera chemistry
Sterols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1976-3786
- Volume :
- 32
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 20162396
- Full Text :
- https://doi.org/10.1007/s12272-009-2205-y