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Oral administration of paramylon, a beta-1,3-D-glucan isolated from Euglena gracilis Z inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2010 Jun; Vol. 72 (6), pp. 755-63. Date of Electronic Publication: 2010 Feb 16. - Publication Year :
- 2010
-
Abstract
- Paramylon is a beta-1,3-D-glucan isolated from Euglena gracilis Z. This study was designed to evaluate the suppressive effects of the oral administration of paramylon on the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) in sensitized NC/Nga mice. The effects of paramylon were assessed by measuring macroscopical and histopathological findings of skin, ear swelling, serum levels of total IgE, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon inhibited the development of AD-like skin lesions as exemplified by a significant decrease in dermatitis scores for the back, ear swelling and hypertrophy of the skin, infiltration of inflammatory cells in the skin, and serum IgE levels. Oral administration of paramylon reduced serum levels of both IL-4 and IFN-gamma and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon did not cause weight loss, as was observed with prednisolone. These results suggest that paramylon inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing both the T-helper (Th) 1 and Th 2 cell responses. Our results indicate that paramylon treatment could provide an effective alternative therapy for the management of AD.
- Subjects :
- Administration, Oral
Animals
Dermatitis, Atopic pathology
Dermatitis, Atopic prevention & control
Ear anatomy & histology
Ear pathology
Enzyme-Linked Immunosorbent Assay
Euglena gracilis chemistry
Glucans administration & dosage
Glucans isolation & purification
Immunization veterinary
Mice
Mice, Inbred Strains
Picryl Chloride pharmacology
Skin drug effects
Dermatitis, Atopic veterinary
Glucans pharmacology
Skin pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0916-7250
- Volume :
- 72
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 20160419
- Full Text :
- https://doi.org/10.1292/jvms.09-0526