Back to Search
Start Over
Dose effects of triazolam and alcohol on cognitive performance in healthy volunteers.
- Source :
-
Experimental and clinical psychopharmacology [Exp Clin Psychopharmacol] 2010 Feb; Vol. 18 (1), pp. 1-16. - Publication Year :
- 2010
-
Abstract
- Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, placebo-controlled, repeated measures study directly compared the acute dose effects of triazolam (0.125, 0.25 mg/70 kg) and alcohol (0.40, 0.80 g/kg) in 20 social drinkers. At doses that produced comparable psychomotor impairment, triazolam was more likely to impair several objective measures of cognitive performance (e.g., episodic memory, divided attention) and to slow performance across several measures. However, only alcohol impaired accuracy on the digit symbol substitution and semantic memory tasks. In addition to objective measures, both drugs impaired awareness of performance impairments (i.e., metacognition) such that participants overestimated impairment, and the magnitude of this effect was generally larger for alcohol. Only triazolam impaired other measures of metacognition (e.g., error detection on a choice reaction time task). Future research might examine the clinical implications of the performance impairments reported here given the widespread use of benzodiazepines and alcohol.<br /> ((PsycINFO Database Record (c) 2010 APA, all rights reserved).)
- Subjects :
- Adult
Cognition physiology
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Male
Middle Aged
Psychomotor Performance physiology
Reaction Time drug effects
Reaction Time physiology
Young Adult
Cognition drug effects
Ethanol administration & dosage
Psychomotor Performance drug effects
Triazolam administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2293
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Experimental and clinical psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 20158290
- Full Text :
- https://doi.org/10.1037/a0018407