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Structure-activity relationships of aromadendranes in uterus-relaxant activity.
- Source :
-
Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2009 Nov-Dec; Vol. 64 (11-12), pp. 840-6. - Publication Year :
- 2009
-
Abstract
- Aromadendranes belong to a class of sesquiterpenes present in higher plant essential oils and marine animals. Although the biological activities include antifungal, antibacterial, antiviral, plant growth regulatory, antifeedant, repellent and cytotoxic, there is only one precedent for spasmolytic effects. In a previous report we have shown that the aromadendrene molecule known as spathulenol, isolated from Lepechinia caulescens, efficiently relaxes rat uterus rings and therefore in the present work we describe structure-activity relationships of thirteen aromadendranes, most of them having the trans-fused perhydroazulene skeleton, with spasmolytic activity.
- Subjects :
- Animals
Dose-Response Relationship, Drug
Female
Magnetic Resonance Spectroscopy
Muscle Relaxation drug effects
Parasympatholytics pharmacology
Rats
Rats, Wistar
Sesquiterpenes, Guaiane
Uterus drug effects
Neuromuscular Depolarizing Agents pharmacology
Sesquiterpenes pharmacology
Uterus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0939-5075
- Volume :
- 64
- Issue :
- 11-12
- Database :
- MEDLINE
- Journal :
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Publication Type :
- Academic Journal
- Accession number :
- 20158155
- Full Text :
- https://doi.org/10.1515/znc-2009-11-1214