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Prevention of mother-to-child transmission of HIV in Denmark, 1994-2008.
- Source :
-
HIV medicine [HIV Med] 2010 Aug; Vol. 11 (7), pp. 448-56. Date of Electronic Publication: 2010 Feb 08. - Publication Year :
- 2010
-
Abstract
- Objectives: The aim of this study was to describe trends in the management of pregnancies in HIV-infected women and their outcomes over a 14-year period in Denmark on a national basis.<br />Methods: The study was a retrospective cohort study of all HIV-infected women in Denmark giving birth to one or more children between 1 June 1994 and 30 June 2008.<br />Results: We identified 210 HIV-infected women with 255 pregnancies, ranging from 7 per year in 1995 to 39 per year in 2006. Thirty per cent of the women were Caucasian and 51% were Black African. Knowledge of HIV status before pregnancy increased from 8% (four of 49) in 1994-1999 to 80% (164 of 206) in 2000-2008. Only 29% (53 of 183) of the women chose to consult an infectious disease specialist when planning pregnancy, while 14% (27 of 199) received assistance with fertility. The proportion of women on antiretroviral therapy (ART) increased from 76% (37 of 49) in 1994-1999 to 98% (201 of 206) in 2000-2008. Vaginal deliveries ranged from 0 in 2003 to 35% of pregnancies in 2007. Mother-to-child transmission (MTCT) of HIV decreased from 10.4% in 1994-1999 to 0.5% in 2000-2008. All women giving birth to an HIV-positive child were diagnosed with HIV during or after delivery and did not receive prophylactic ART.<br />Conclusions: The annual number of HIV pregnancies increased fivefold during this 14-year period and substantial changes in pregnancy management were seen. No woman treated according to the national guidelines, i.e. ART before week 22, intravenous zidovudine (ZDV) during labour, neonatal ZDV for 4 to 6 weeks and no breastfeeding, transmitted HIV to her child.
- Subjects :
- Adolescent
Adult
Anti-Retroviral Agents therapeutic use
Asian People
Black People
Breast Feeding statistics & numerical data
CD4 Lymphocyte Count
Cesarean Section trends
Denmark epidemiology
Female
Gestational Age
HIV Infections drug therapy
HIV Infections epidemiology
HIV Infections transmission
Health Knowledge, Attitudes, Practice
Humans
Infant
Infectious Disease Transmission, Vertical statistics & numerical data
Middle Aged
Pregnancy
Pregnancy Complications, Infectious drug therapy
Pregnancy Outcome epidemiology
Retrospective Studies
Risk Factors
Viral Load
Young Adult
Antiretroviral Therapy, Highly Active trends
HIV Infections prevention & control
Infectious Disease Transmission, Vertical prevention & control
Pregnancy Complications, Infectious epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-1293
- Volume :
- 11
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- HIV medicine
- Publication Type :
- Academic Journal
- Accession number :
- 20146735
- Full Text :
- https://doi.org/10.1111/j.1468-1293.2009.00811.x