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Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission.
- Source :
-
International journal of hematology [Int J Hematol] 2010 Apr; Vol. 91 (3), pp. 419-25. Date of Electronic Publication: 2010 Feb 10. - Publication Year :
- 2010
-
Abstract
- The indication of allogeneic stem cell transplantation (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia [Ph(-) ALL] from unrelated donors is not established. To assess its potency of unrelated patients in first complete-remission (CR1) transplanted from unrelated donors and the potential prognostic factors affecting the probability of survival, we retrospectively analyzed a total of 41 adult Ph(-) ALL patients in CR1 who underwent unrelated bone marrow transplantation at 6 transplantation centers of the Nagoya Blood and Marrow Transplantation Group between 1993 and 2006. The median age of the 41 patients was 28 years (range, 18-51 years). HLA was matched in 33 transplants, with mismatches in 8 (HLA-A allele mismatch:1, HLA-DR serological mismatch: 2, HLA-DRB1 mismatch: 5). Leukemia-free survival (LFS) at 3 and 6 years from allo-SCT was 60.3 and 47.7%, respectively. LFS at 5 years was 62.1% for those transplanted from HLA-matched donors. LFS was significantly lower with HLA-mismatched donors due to higher transplantation-related mortality. Relapse was observed in 3 patients. Our study suggested that unrelated allo-SCT could improve LFS of patients with a potential graft-versus-leukemia effect. Unrelated allo-SCT for Ph(-) ALL patients in CR1 could be more beneficial by reducing TRM, such as selecting a HLA-matched donor.
- Subjects :
- Adolescent
Adult
Bone Marrow Transplantation adverse effects
Cohort Studies
Disease-Free Survival
Female
Follow-Up Studies
Graft vs Host Disease immunology
Graft vs Host Disease mortality
Humans
Incidence
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma mortality
Prognosis
Remission Induction
Retrospective Studies
Tissue Donors
Transplantation, Homologous
Treatment Outcome
Young Adult
Bone Marrow Transplantation immunology
Histocompatibility immunology
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 91
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 20146028
- Full Text :
- https://doi.org/10.1007/s12185-010-0509-9