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The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2010 Dec; Vol. 1802 (12), pp. 1237-45. Date of Electronic Publication: 2010 Feb 06. - Publication Year :
- 2010
-
Abstract
- The Na/K-ATPase was discovered as an energy transducing ion pump. A major difference between the Na/K-ATPase and other P-type ATPases is its ability to bind a group of chemicals called cardiotonic steroids (CTS). The plant-derived CTS such as digoxin are valuable drugs for the management of cardiac diseases, whereas ouabain and marinobufagenin (MBG) have been identified as a new class of endogenous hormones. Recent studies have demonstrated that the endogenous CTS are important regulators of renal Na(+) excretion and blood pressure. The Na/K-ATPase is not only an ion pump, but also an important receptor that can transduce the ligand-like effect of CTS on intracellular protein kinases and Ca(2+) signaling. Significantly, these CTS-provoked signaling events are capable of reducing the surface expression of apical NHE3 (Na/H exchanger isoform 3) and basolateral Na/K-ATPase in renal proximal tubular cells. These findings suggest that endogenous CTS may play an important role in regulation of tubular Na(+) excretion under physiological conditions; conversely, a defect at either the receptor level (Na/K-ATPase) or receptor-effector coupling would reduce the ability of renal proximal tubular cells to excrete Na(+), thus culminating/resulting in salt-sensitive hypertension.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Humans
Hypertension metabolism
Hypertension pathology
Hypertension physiopathology
Kidney Tubules, Proximal pathology
Kidney Tubules, Proximal physiopathology
Protein Transport
Sodium-Hydrogen Exchanger 3
Sodium-Hydrogen Exchangers metabolism
Bufanolides metabolism
Calcium Signaling
Kidney Tubules, Proximal metabolism
Ouabain metabolism
Protein Kinases metabolism
Sodium-Potassium-Exchanging ATPase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1802
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 20144708
- Full Text :
- https://doi.org/10.1016/j.bbadis.2010.01.013