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Genome-wide association study of hematological and biochemical traits in a Japanese population.
- Source :
-
Nature genetics [Nat Genet] 2010 Mar; Vol. 42 (3), pp. 210-5. Date of Electronic Publication: 2010 Feb 07. - Publication Year :
- 2010
-
Abstract
- We report genome-wide association studies for hematological and biochemical traits from approximately 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 x 10(-8)). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.
- Subjects :
- Biomarkers analysis
Blood Cell Count
Blood Chemical Analysis
Cohort Studies
Erythrocytes cytology
Erythrocytes pathology
Gene Frequency
Genetics, Population
Hematologic Diseases blood
Hematologic Diseases genetics
Hematologic Diseases pathology
Hematologic Tests
Humans
Polymorphism, Single Nucleotide
Uric Acid blood
Asian People genetics
Biomarkers blood
Genome-Wide Association Study
Quantitative Trait Loci
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 20139978
- Full Text :
- https://doi.org/10.1038/ng.531