Back to Search Start Over

Beyond lowering circulating LDL: apheresis-induced changes of systemic oxidative stress markers by four different techniques.

Authors :
Kopprasch S
Graessler J
Bornstein SR
Schwarz PE
Tselmin S
Frind A
Poberschin I
Julius U
Source :
Atherosclerosis. Supplements [Atheroscler Suppl] 2009 Dec 29; Vol. 10 (5), pp. 34-8.
Publication Year :
2009

Abstract

Objective and Methods: Dyslipidemia and oxidative stress are causally related to atherogenesis and cardiovascular disease. We assessed acute changes of systemic oxidative stress biomarkers in thirty-two patients undergoing regular apheresis using four different techniques: heparin-induced extracorporeal LDL precipitation (HELP), direct adsorption of lipoproteins (DALI), lipidfiltration (LF), and immunoadsorption of lipoproteins (IA).<br />Results: All apheresis procedures were similarly effective in lowering LDL cholesterol (-2.5+/-0.2 mmoL/L), oxidized LDL (-52.4+/-4.4 U/L), and levels of antioxLDL antibodies (-59.5+/-15.1 U/L). Among the LDL-apheresis methods investigated, only the DALI technique without prior separation of blood plasma led to a decline in leukocyte count (p=0.01 vs. LF post apheresis) and to decreased phagocyte oxidant-generating activity as evaluated by chemiluminescence. Moreover, DALI was followed by a smaller decrease of blood total antioxidant capacity than the other techniques (p<0.01 vs. HELP post apheresis).<br />Conclusion: Together, our data suggest that compared with other common techniques, the DALI apheresis system is accompanied by the lowest systemic oxidative burden evoked by a single apheresis treatment.<br /> (Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1878-5050
Volume :
10
Issue :
5
Database :
MEDLINE
Journal :
Atherosclerosis. Supplements
Publication Type :
Academic Journal
Accession number :
20129371
Full Text :
https://doi.org/10.1016/S1567-5688(09)71807-0