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[Seroprevalence of hepatitis B virus and human immunodeficiency virus infection in a population of multiply-transfused patients in Colombia].
- Source :
-
Biomedica : revista del Instituto Nacional de Salud [Biomedica] 2009 Jun; Vol. 29 (2), pp. 232-43. - Publication Year :
- 2009
-
Abstract
- Introduction: Although the transfusion of blood products is a common therapy, it carries risk of transmission of infections, especially hepatitus B virus (HBV) and human immunodeficiency virus (HIV).<br />Objective: As part of the blood safety initiative, the Pan American Health Organization supported studies to estimate the prevalence of human immunodeficiency virus and hepatitis B virus infection in Colombia.<br />Materials and Methods: Between February and September 2003, a cross sectional study examined 500 multiply-transfused patients at four hospital centers in the cities of Bogota and Medellin. The serum samples were analyzed by enzyme immunoassay (EIA) using commercial kits.<br />Results: The seroprevalence of HIV infection was 1.8% (CI 95% 0.5-3.1). The seroprevalence of HBV infection was 18.6% (CI 95% 15.1-22.1). Six risk factors were associated with HIV and HBV infection: (1) receiving more than 48 units of blood or blood components, (2) diagnosis of hemophilia, (3) receiving transfusions for more than one year, (4) receiving whole blood, (5) coinfection with hepatitis C virus and (6) receiving transfusions before 1993.<br />Conclusions: This is the first epidemiological study with a significant sample size performed in multiply-transfused patients in Colombia. The principal finding was the high prevalence of HBV and HIV infection in patients with diagnosis of hemophilia compared with the other five groups of multiply-transfused patients.
- Subjects :
- Blood Transfusion statistics & numerical data
Colombia
Comorbidity
Cross-Sectional Studies
HIV Infections transmission
Hemoglobinopathies epidemiology
Hemoglobinopathies therapy
Hemophilia A epidemiology
Hemophilia A therapy
Hemorrhage epidemiology
Hemorrhage therapy
Hepatitis B transmission
Hepatitis C epidemiology
Humans
Kidney Failure, Chronic epidemiology
Kidney Failure, Chronic therapy
Neoplasms epidemiology
Neoplasms therapy
Renal Dialysis
Risk Factors
Seroepidemiologic Studies
HIV Infections epidemiology
Hepatitis B epidemiology
Transfusion Reaction
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0120-4157
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biomedica : revista del Instituto Nacional de Salud
- Publication Type :
- Academic Journal
- Accession number :
- 20128348