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ZAC1 target genes and pituitary tumorigenesis.
- Source :
-
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2010 Sep 15; Vol. 326 (1-2), pp. 60-5. Date of Electronic Publication: 2010 Feb 01. - Publication Year :
- 2010
-
Abstract
- The zinc-finger protein Zac1 has a role as transcription factor and coregulator and plays an important role in pituitary development, maturation and tumorigenesis. Zac1 target genes control cell proliferation and hormone synthesis. While Zac1 is highly expressed in all hormone-producing cells of the pituitary, loss of expression frequently occurs in pituitary adenomas, in particular in non-functioning tumors. Zac1 lies downstream to the mitogenic MAPK and survival PI3K pathways. In turn, inhibition of the PI3K pathway by therapeutic agents, like somatostatin analogs up-regulate Zac1 expression. In fact Zac1 is an essential mediator of the antiproliferative effects of this treatment and correlates to successful outcome in acromegalic patients.<br /> (2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Cell Cycle Proteins genetics
Cyclins metabolism
DNA-Binding Proteins metabolism
Humans
Mice
Nuclear Receptor Coactivators metabolism
Pituitary Gland metabolism
Pituitary Gland pathology
Pituitary Neoplasms pathology
Somatostatin metabolism
Zinc Fingers genetics
p300-CBP Transcription Factors metabolism
Cell Cycle Proteins metabolism
Pituitary Neoplasms genetics
Transcription Factors metabolism
Tumor Suppressor Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8057
- Volume :
- 326
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular and cellular endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 20117169
- Full Text :
- https://doi.org/10.1016/j.mce.2010.01.033