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Relationship between cholesterol synthesis and intestinal absorption is associated with cardiovascular risk.
- Source :
-
Atherosclerosis [Atherosclerosis] 2010 Jun; Vol. 210 (2), pp. 362-5. Date of Electronic Publication: 2010 Jan 15. - Publication Year :
- 2010
-
Abstract
- Hypercholesterolemia is a major risk factor for cardiovascular disease. The HMG-CoA-reductase inhibitors, statins, reduce plasma cholesterol and, as a consequence, decrease cardiovascular morbidity and mortality. Data from a subgroup analysis of the 4-S Study, however, indicate that patients with high cholesterol absorption may not benefit from statin treatment. Furthermore, there is accumulating evidence that lower hepatic synthesis and higher intestinal absorption markers are associated with increased cardiovascular risk. Therefore, prospective clinical trials are needed to evaluate whether subjects with altered cholesterol homeostasis may benefit from treatment strategies that reduce cholesterol absorption in addition to statin treatment.<br /> (Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Absorption
Anticholesteremic Agents pharmacology
Cholesterol blood
Coronary Disease metabolism
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors metabolism
Hypercholesterolemia metabolism
Liver metabolism
Phytosterols pharmacology
Risk
Sterols pharmacology
Cardiovascular Diseases metabolism
Cholesterol metabolism
Hypercholesterolemia diagnosis
Intestinal Mucosa metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 210
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 20116793
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2010.01.003