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[Intraperitoneal chemotherapy in the treatment of advanced ovarian cancer].

[Intraperitoneal chemotherapy in the treatment of advanced ovarian cancer].

Authors :
Classe JM
Muller M
Frenel JS
Berton Rigaud D
Ferron G
Jaffré I
Gladieff L
Source :
Journal de gynecologie, obstetrique et biologie de la reproduction [J Gynecol Obstet Biol Reprod (Paris)] 2010 May; Vol. 39 (3), pp. 183-90. Date of Electronic Publication: 2010 Jan 29.
Publication Year :
2010

Abstract

The standard treatment for advanced ovarian cancer consist in complete surgical debulking and intravenous platin and taxane based chemotherapy. Despite research efforts, a lot of patients still die from peritoneal carcinomatosis. The aim of our work was to present the state of art about intraperitoneal chemotherapy. Intraperitoneal chemotherapy (IPC): three multi-institutional randomised trials showed that platin based IPC gave better results in term of overall and disease free survival when compared to standard intravenous treatment. Even so, IPC is not yet becoming a new international standard of treatment because a high rate of morbidity. Hyperthermic Intraperitoneal chemotherapy (HIPEC) represents an innovative alternative to IPC. HIPEC is based on a complete surgical debulking without any visible mass and an intraperitoneal chemotherapy with synergy of hyperthermia. Phase II trails have shown its feasibility. Randomised trials are needed to assess its efficiency in improving survival.<br /> (Copyright 2010 Elsevier Masson SAS. All rights reserved.)

Details

Language :
French
ISSN :
1773-0430
Volume :
39
Issue :
3
Database :
MEDLINE
Journal :
Journal de gynecologie, obstetrique et biologie de la reproduction
Publication Type :
Academic Journal
Accession number :
20116179
Full Text :
https://doi.org/10.1016/j.jgyn.2009.12.007