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Keratocystic odontogenic tumor associated with nevoid basal cell carcinoma syndrome: similar behavior to sporadic type?
- Source :
-
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2010 Feb; Vol. 142 (2), pp. 179-83. - Publication Year :
- 2010
-
Abstract
- Objective: The objective of this study was to analyze the expression of proliferative markers and p53 in keratocystic odontogenic tumor (KCOT) sporadic type and KCOT associated with nevoid basal cell carcinoma syndrome (NBCCS).<br />Study Design and Setting: We performed a cross-sectional study. A total of 19 patients with KCOT were selected from the Oral Pathology Laboratory archives, Central University of Venezuela, from 1995 to 2005.<br />Subjects and Methods: Twelve cases corresponded to sporadic KCOT, and seven cases were associated with NBCCS. Immunohistochemical analysis for p53, proliferating cell nuclear antigen (PCNA), and Ki-67 was performed in all 19 cases.<br />Results: Of the seven cases associated with NBCCS, six (86%) were positive for PCNA. From the 12 sporadic cases, nine (75%) were positive for PCNA. Only one case of sporadic KCOT showed Ki-67 positivity. Five of 12 (42%) cases of sporadic KCOT were positive for p53, and only one (14%) case associated with NBCCS was positive for p53.<br />Conclusion: On the basis of the analysis of the expression of PCNA, Ki-67, and p53, there appears to be no evidence to indicate higher aggressiveness in growth and infiltrative behavior in syndromic KCOT compared with the sporadic type. Therefore, surgical treatment may be approached in the same manner in KCOT sporadic and syndromic with the goal of minimizing recurrence.<br /> (Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.)
- Subjects :
- Cross-Sectional Studies
Humans
Immunohistochemistry
Ki-67 Antigen analysis
Neoplasm Invasiveness
Odontogenic Cysts chemistry
Odontogenic Cysts surgery
Proliferating Cell Nuclear Antigen analysis
Tumor Suppressor Protein p53 analysis
Basal Cell Nevus Syndrome metabolism
Basal Cell Nevus Syndrome pathology
Biomarkers, Tumor analysis
Odontogenic Cysts metabolism
Odontogenic Cysts pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6817
- Volume :
- 142
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 20115971
- Full Text :
- https://doi.org/10.1016/j.otohns.2009.10.008