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Coexistence of alternative MLL-SEPT9 fusion transcripts in an acute myeloid leukemia with t(11;17)(q23;q25).
- Source :
-
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2010 Feb; Vol. 197 (1), pp. 60-4. - Publication Year :
- 2010
-
Abstract
- We present the characterization at the RNA level of an acute myeloid leukemia with a t(11;17)(q23;q25) and a MLL rearrangement demonstrated by FISH. Molecular analysis led to the identification of two coexistent in-frame MLL-SEPT9 fusion transcripts (variants 1 and 2), presumably resulting from alternative splicing. Real-time quantitative RT-PCR analysis showed that the relative expression of the MLL-SEPT9 fusion variant 2 was 1.88 fold higher than the relative expression of MLL-SEPT9 fusion variant 1. This is the first description of a MLL-SEPT9 fusion resulting in coexistence of two alternative splicing variants, each of which previously found isolated in myeloid leukemias.<br /> (Copyright (c) 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Alternative Splicing
Child
Histone-Lysine N-Methyltransferase
Humans
Infant
Male
Middle Aged
Septins
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Cytoskeletal Proteins genetics
GTP-Binding Proteins genetics
Leukemia, Myeloid, Acute genetics
Myeloid-Lymphoid Leukemia Protein genetics
Oncogene Proteins, Fusion genetics
RNA, Messenger analysis
Translocation, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4456
- Volume :
- 197
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer genetics and cytogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 20113838
- Full Text :
- https://doi.org/10.1016/j.cancergencyto.2009.10.010