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Histone acetylation and histone synthesis in mouse fibroblasts during quiescence and restimulation into S-phase.

Authors :
Knosp O
Talasz H
Puschendorf B
Source :
Molecular and cellular biochemistry [Mol Cell Biochem] 1991 Feb 27; Vol. 101 (1), pp. 51-8.
Publication Year :
1991

Abstract

Mouse NIH 3T3 fibroblasts were starved by serum depletion and subsequently restimulated by addition of serum. Histone acetylation and histone synthesis were studied from the beginning of starvation to the point where most of the cells were in S-phase utilizing electrophoretic and fluorographic techniques. We found that the major part of histone acetylation and histone synthesis occurs during S-phase but that also in the absence of DNA synthesis there are significant changes in the acetylation and synthesis rates of the core histones which occur during the first 6 hours of serum stimulation of quiescent cells, and between 24 and 48 hours of serum starvation.

Details

Language :
English
ISSN :
0300-8177
Volume :
101
Issue :
1
Database :
MEDLINE
Journal :
Molecular and cellular biochemistry
Publication Type :
Academic Journal
Accession number :
2011118
Full Text :
https://doi.org/10.1007/BF00238437