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A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

Authors :
Durrant JD
Amaro RE
Xie L
Urbaniak MD
Ferguson MA
Haapalainen A
Chen Z
Di Guilmi AM
Wunder F
Bourne PE
McCammon JA
Source :
PLoS computational biology [PLoS Comput Biol] 2010 Jan 22; Vol. 6 (1), pp. e1000648. Date of Electronic Publication: 2010 Jan 22.
Publication Year :
2010

Abstract

Conventional drug design embraces the "one gene, one drug, one disease" philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery. The rational design of drugs that act via polypharmacological mechanisms can produce compounds that exhibit increased therapeutic potency and against which resistance is less likely to develop. Additionally, identifying multiple protein targets is also critical for side-effect prediction. One third of potential therapeutic compounds fail in clinical trials or are later removed from the market due to unacceptable side effects often caused by off-target binding. In the current work, we introduce a multidimensional strategy for the identification of secondary targets of known small-molecule inhibitors in the absence of global structural and sequence homology with the primary target protein. To demonstrate the utility of the strategy, we identify several targets of 4,5-dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, a known micromolar inhibitor of Trypanosoma brucei RNA editing ligase 1. As it is capable of identifying potential secondary targets, the strategy described here may play a useful role in future efforts to reduce drug side effects and/or to increase polypharmacology.

Details

Language :
English
ISSN :
1553-7358
Volume :
6
Issue :
1
Database :
MEDLINE
Journal :
PLoS computational biology
Publication Type :
Academic Journal
Accession number :
20098496
Full Text :
https://doi.org/10.1371/journal.pcbi.1000648