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Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2010 Mar; Vol. 32 (2), pp. 128-30. - Publication Year :
- 2010
-
Abstract
- Invasive fungal infections are serious complications of cancer therapy. We present a case report of a 12-year-old boy diagnosed with abdominal non-Hodgkin lymphoma and fecal and Candida peritonitis during induction chemotherapy. The invasive mycosis was managed using a combined approach of systemic antifungal agents including efungumab and surgical interventions. Efungumab, a recombinant antibody that inhibits extracellular heat shock protein 90, was used in combination with amphotericin B colloid dispersion after the failure of standard approaches.
- Subjects :
- Abdominal Neoplasms drug therapy
Antibodies, Monoclonal, Humanized
Child
Drug Therapy, Combination
Humans
Lymphoma, Non-Hodgkin drug therapy
Male
Abdominal Neoplasms complications
Amphotericin B administration & dosage
Antibodies, Monoclonal administration & dosage
Antifungal Agents administration & dosage
Candidiasis drug therapy
HSP90 Heat-Shock Proteins antagonists & inhibitors
Lymphoma, Non-Hodgkin complications
Peritonitis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 20098335
- Full Text :
- https://doi.org/10.1097/MPH.0b013e3181cb49a8