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Reversibility of the effects of the chemotherapeutic regimen for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone, on the male rat reproductive system and progeny outcome.
- Source :
-
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2010 Jun; Vol. 29 (3), pp. 332-8. Date of Electronic Publication: 2010 Jan 22. - Publication Year :
- 2010
-
Abstract
- The chemotherapeutic agents used to treat non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), have adverse effects on male reproductive function and progeny outcome. To determine the reversibility of these effects, male rats received a CHOP treatment mimicking human exposure. CHOP reduced testicular and epididymal weights; these remained decreased after 9 weeks recovery. This treatment also decreased testicular sperm number and increased spermatozoal DNA damage. Although sperm production returned to control values after 9 weeks recovery, DNA damage persisted. Decreased litter size, and increased pre- and post-implantation losses were observed among litters sired by CHOP-exposed males. Litter size and pre-implantation loss returned to control within 3 weeks post-treatment and post-implantation loss by 6 weeks. Thus, effects of CHOP on progeny outcome were reversed 9 weeks post-treatment, although germ cell DNA breaks remained elevated. These data suggest that the ability to sire viable progeny may not be a sensitive measure of spermatozoal quality in rats.<br /> (Copyright 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Antineoplastic Combined Chemotherapy Protocols
Clinical Protocols
Epididymis drug effects
Female
Humans
Litter Size drug effects
Male
Prednisone pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
Reproduction drug effects
Sperm Count
Spermatozoa drug effects
Testis drug effects
Treatment Outcome
Vincristine pharmacology
Antineoplastic Agents therapeutic use
Cyclophosphamide adverse effects
Cyclophosphamide pharmacology
Cyclophosphamide therapeutic use
Doxorubicin pharmacology
Doxorubicin therapeutic use
Lymphoma, Non-Hodgkin drug therapy
Prednisone therapeutic use
Vincristine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1708
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 20096776
- Full Text :
- https://doi.org/10.1016/j.reprotox.2010.01.007