Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.

Authors :: Huang L
Muthuswamy SK
Source :: Current opinion in genetics & development [Curr Opin Genet Dev] 2010 Feb; Vol. 20 (1), pp. 41-50. Date of Electronic Publication: 2010 Jan 21.
Publication Year :: 2010
Abstract: In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis.<br /> (Copyright 2009 Elsevier Ltd. All rights reserved.)

Subjects :: Adaptor Proteins, Signal Transducing
Animals
Apoptosis
Cell Cycle Proteins metabolism
Cell Movement
Cell Proliferation
Eye Proteins metabolism
Gene Expression
Humans
Nerve Tissue Proteins metabolism
Nucleoside-Phosphate Kinase metabolism
Carcinoma genetics
Carcinoma metabolism
Cell Polarity genetics
Membrane Proteins genetics
Membrane Proteins metabolism
Neoplasms genetics
Neoplasms metabolism

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