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Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy.
- Source :
-
International journal of clinical oncology [Int J Clin Oncol] 2010 Feb; Vol. 15 (1), pp. 88-92. Date of Electronic Publication: 2010 Jan 21. - Publication Year :
- 2010
-
Abstract
- Pancreatic lipomatosis is characterized as massive lipid infiltration of the pancreatic tissue. Although its etiology is ill defined; obesity, diabetes mellitus, chronic pancreatitis, hereditary pancreatitis, and conditions that cause pancreatic ductal obstruction, for example tumors and stones, are related to its pathogenesis. Recently, with the increased use of computerized tomography and magnetic resonance imaging, it has become possible to observe the fat replacement of the pancreas. Herein, we report a 60-year-old man complaining of abdominal pain and weight loss. Preoperative work-up revealed a locally advanced (Stage III) pancreatic adenocarcinoma. Multimodal treatment was carried out and a 100% complete response was detected after neoadjuvant therapy. The patient underwent a standard pancreaticoduodenectomy, without complications. The tissue pathology revealed lipomatosis of the pancreas. He was disease-free and symptom-free at 1 year follow-up. To our knowledge, this is the first report in the literature of pancreatic head carcinoma with total fat replacement of the pancreas after neoadjuvant chemoradiotherapy.
- Subjects :
- Adenocarcinoma surgery
Adenocarcinoma therapy
Combined Modality Therapy
Humans
Male
Middle Aged
Neoadjuvant Therapy
Pancreatic Diseases complications
Pancreatic Neoplasms surgery
Pancreatic Neoplasms therapy
Pancreaticoduodenectomy
Adenocarcinoma complications
Lipomatosis complications
Pancreatic Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7772
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 20091080
- Full Text :
- https://doi.org/10.1007/s10147-009-0001-9