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Does pretreatment with lansoprazole influence Helicobacter pylori eradication rate and quality of life?
- Source :
-
Digestion [Digestion] 2010; Vol. 81 (4), pp. 218-22. Date of Electronic Publication: 2010 Jan 20. - Publication Year :
- 2010
-
Abstract
- Background/aims: It is controversial whether pretreatment with a proton pump inhibitor (PPI) before Helicobacter pylori eradication treatment decreases the eradication rate. To determine the effects of pretreatment with lansoprazole alone, followed by an H. pylori eradication regimen (lansoprazole 30 mg, amoxicillin 750 mg and clarithromycin 200 mg twice daily for 1 week), on the eradication rate and quality of life (QoL) of the patient.<br />Methods: Patients with H. pylori-positive peptic ulcer were randomly assigned to two groups. The patients received either lansoprazole (30 mg) once daily for 6-8 weeks before H. pylori eradication (group A), or eradication treatment and then lansoprazole (30 mg) for 6-8 weeks (group B). To assess the QoL of the patients, the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire was evaluated.<br />Results: A total of 116 patients were enrolled. The cure rates were 78.9% in group A and 78.0% in group B. In both groups, GSRS analysis showed a significant improvement of the overall GSRS score at the assessment of eradication efficacy, compared to baseline; there was no difference between the groups.<br />Conclusion: With this H. pylori eradication regimen, there was no difference in the cure rates and QoL associated with PPI pretreatment.
- Subjects :
- Administration, Oral
Adult
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Duodenal Ulcer drug therapy
Duodenal Ulcer microbiology
Duodenal Ulcer pathology
Female
Follow-Up Studies
Helicobacter Infections diagnosis
Helicobacter pylori isolation & purification
Humans
Lansoprazole
Logistic Models
Male
Middle Aged
Proton Pump Inhibitors administration & dosage
Risk Assessment
Severity of Illness Index
Statistics, Nonparametric
Stomach Ulcer drug therapy
Stomach Ulcer microbiology
Stomach Ulcer pathology
Treatment Outcome
2-Pyridinylmethylsulfinylbenzimidazoles administration & dosage
Amoxicillin administration & dosage
Clarithromycin administration & dosage
Helicobacter Infections drug therapy
Helicobacter pylori drug effects
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9867
- Volume :
- 81
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Digestion
- Publication Type :
- Academic Journal
- Accession number :
- 20090337
- Full Text :
- https://doi.org/10.1159/000260416