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In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2010 Apr; Vol. 54 (4), pp. 1636-8. Date of Electronic Publication: 2010 Jan 19. - Publication Year :
- 2010
-
Abstract
- The in vitro activities of eight antifungal drugs against clinical isolates of Fonsecaea pedrosoi (n = 21), Fonsecaea monophora (n = 25), and Fonsecaea nubica (n = 9) were tested. The resulting MIC(90)s for all strains (n = 55) were as follows, in increasing order: posaconazole, 0.063 microg/ml; itraconazole, 0.125 microg/ml; isavuconazole, 0.25 microg/ml; voriconazole, 0.5 microg/ml; amphotericin B, 2 microg/ml; caspofungin, 2 microg/ml; anidulafungin, 2 microg/ml; and fluconazole, 32 microg/ml.
- Subjects :
- Amphotericin B pharmacology
Anidulafungin
Ascomycota isolation & purification
Caspofungin
Drug Resistance, Fungal
Echinocandins pharmacology
Fluconazole pharmacology
Humans
In Vitro Techniques
Itraconazole pharmacology
Lipopeptides
Microbial Sensitivity Tests
Nitriles pharmacology
Pyridines pharmacology
Pyrimidines pharmacology
Triazoles pharmacology
Voriconazole
Antifungal Agents pharmacology
Ascomycota drug effects
Chromoblastomycosis drug therapy
Chromoblastomycosis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 20086140
- Full Text :
- https://doi.org/10.1128/AAC.01655-09