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Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model.
- Source :
-
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2010 May; Vol. 37 (5-6), pp. 587-92. Date of Electronic Publication: 2010 Jan 17. - Publication Year :
- 2010
-
Abstract
- 1. Many studies have evaluated the effectiveness of alpha-tocopherol (vitamin E) in the development and progression of cardiovascular diseases, with conflicting results reported on the protective effect of this anti-oxidant. 2. The present study examined the effectiveness of a novel tocopheryl phosphate mixture (TPm) compared with that of alpha-tocopherol (TA) on key pro-inflammatory markers involved in atherogenesis, including interleukin (IL)-1beta, IL-6, IL-8, plasminogen activator inhibitor-1, tumour necrosis factor-alpha and C-reactive protein (CRP), as well as vascular function and lesion development in rabbits fed a 2% cholesterol diet. 3. Treatment with TPm, incorporated into the rabbit food at four doses ranging from 60 to 360 mg/kg chow, resulted in a significant reduction in plasma levels of all pro-inflammatory cytokines and biomarkers that appeared to be somewhat dose dependent. Conversely, treatment with TA, at a dose equivalent to the highest dose of TPm used, only decreased plasma levels of CRP, IL-6 and IL-8. Both TPm and TA treatment significantly improved vascular function to a similar extent, although TPm was more effective in reducing lesion development. 4. The reduction in these key pro-inflammatory markers appears to follow the improvement in the atherogenic state of the animals, indicating that the anti-inflammatory properties of TPm may be potentially beneficial in inflammatory disease states.
- Subjects :
- Animals
Antioxidants administration & dosage
Aorta drug effects
Aorta pathology
Aorta physiopathology
Atherosclerosis blood
Atherosclerosis etiology
Atherosclerosis immunology
Atherosclerosis pathology
Biomarkers blood
Cytokines immunology
Diet, Atherogenic
Disease Models, Animal
Dose-Response Relationship, Drug
Hypercholesterolemia blood
Hypercholesterolemia immunology
Hypercholesterolemia pathology
In Vitro Techniques
Lipids blood
Male
Rabbits
Treatment Outcome
Vasodilation drug effects
alpha-Tocopherol administration & dosage
alpha-Tocopherol therapeutic use
Antioxidants therapeutic use
Atherosclerosis prevention & control
Cytokines blood
Hypercholesterolemia complications
alpha-Tocopherol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1681
- Volume :
- 37
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Clinical and experimental pharmacology & physiology
- Publication Type :
- Academic Journal
- Accession number :
- 20082629
- Full Text :
- https://doi.org/10.1111/j.1440-1681.2010.05356.x