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First- and second-line drug resistance patterns among previously treated tuberculosis patients in India.
- Source :
-
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2010 Feb; Vol. 14 (2), pp. 243-6. - Publication Year :
- 2010
-
Abstract
- Culture and drug susceptibility testing results of 2816 tuberculosis (TB) patients from across India who had failed repeated treatments from 2001 to 2004 were retrospectively analysed at the Tuberculosis Research Centre, Chennai. Of 1498 (53%) identified as having multidrug-resistant TB (MDR-TB), 671 (44.8%) were resistant to > or =1 second-line drugs (SLDs): 490 (32.7%) to ethionamide, 245 (16.4%) to ofloxacin and 169 (11.3%) to kanamycin; 69 (4.6%) were extensively drug-resistant TB (XDR-TB). Although from a highly select and non-representative patient group, such high SLD resistance levels, including XDR-TB, among MDR-TB patients is of concern. The prevention of MDR/XDR-TB through quality DOTS services, however, remains the priority. In addition, rapid scale-up of quality programmatic management under the RNTCP is needed, with more control and rational use of SLDs outside the programme.
- Subjects :
- Antitubercular Agents administration & dosage
Directly Observed Therapy methods
Extensively Drug-Resistant Tuberculosis microbiology
Extensively Drug-Resistant Tuberculosis prevention & control
Humans
India epidemiology
Microbial Sensitivity Tests
Mycobacterium tuberculosis isolation & purification
Retrospective Studies
Treatment Failure
Tuberculosis, Multidrug-Resistant microbiology
Tuberculosis, Multidrug-Resistant prevention & control
Antitubercular Agents pharmacology
Extensively Drug-Resistant Tuberculosis epidemiology
Mycobacterium tuberculosis drug effects
Tuberculosis, Multidrug-Resistant epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1815-7920
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
- Publication Type :
- Academic Journal
- Accession number :
- 20074419