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Presynaptic targets for acute ethanol sensitivity.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2010 Feb; Vol. 38 (Pt 1), pp. 172-6. - Publication Year :
- 2010
-
Abstract
- Acute exposure to ethanol is known to modulate signalling within the nervous system. Physiologically these effects are both presynaptic and postsynaptic in origin; however, considerably more research has focused primarily on postsynaptic targets. Recent research using the model organism Caenorhabditis elegans has determined a role for specific proteins (Munc18-1 and Rab3) and processes (synaptic vesicle recruitment and fusion) in transducing the presynaptic effects of ethanol. In the present paper, we review these results, identifying the proteins and protein interactions involved in ethanol sensitivity and discuss their links with mammalian studies of alcohol abuse.
- Subjects :
- Animals
Caenorhabditis elegans cytology
Caenorhabditis elegans metabolism
Caenorhabditis elegans Proteins metabolism
Exocytosis drug effects
Exocytosis physiology
Humans
Munc18 Proteins metabolism
Presynaptic Terminals metabolism
SNARE Proteins metabolism
Synaptic Transmission physiology
rab GTP-Binding Proteins genetics
rab GTP-Binding Proteins metabolism
Ethanol pharmacology
Presynaptic Terminals drug effects
Synaptic Transmission drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1470-8752
- Volume :
- 38
- Issue :
- Pt 1
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 20074054
- Full Text :
- https://doi.org/10.1042/BST0380172