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Infection of in vivo differentiated human mast cells with hantaviruses.
- Source :
-
The Journal of general virology [J Gen Virol] 2010 May; Vol. 91 (Pt 5), pp. 1256-61. Date of Electronic Publication: 2010 Jan 13. - Publication Year :
- 2010
-
Abstract
- Increased vascular permeability is a key feature of the pathological symptoms caused by hantaviruses. Here, we analysed the interaction between hantaviruses and mast cells, which regulate vascular homeostasis. In highly purified human skin mast cells increasing amounts of Hantaan (HTNV) and, to a lower extent, Prospect Hill (PHV) virions were produced. Replication was confirmed by the production of viral plus-strand RNA as determined by a virus strand-specific RT-PCR. PHV but not HTNV elicited early expression of beta interferon, MxA, ISG15 and CCL5 consistent to studies with other cell types. The data demonstrate that mature mast cells are permissive to infection with hantaviruses. This interaction might contribute to the development of vascular leakage syndrome.
- Subjects :
- Cells, Cultured
Chemokine CCL5 biosynthesis
Cytokines biosynthesis
GTP-Binding Proteins biosynthesis
Gene Expression
Humans
Interferon-beta biosynthesis
Myxovirus Resistance Proteins
RNA, Viral biosynthesis
RNA, Viral genetics
Reverse Transcriptase Polymerase Chain Reaction
Ubiquitins biosynthesis
Orthohantavirus physiology
Mast Cells virology
Virus Replication
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2099
- Volume :
- 91
- Issue :
- Pt 5
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 20071485
- Full Text :
- https://doi.org/10.1099/vir.0.019505-0