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Neuropsychological profiles of young people with type 1 diabetes 12 yr after disease onset.
- Source :
-
Pediatric diabetes [Pediatr Diabetes] 2010 Jun; Vol. 11 (4), pp. 235-43. Date of Electronic Publication: 2010 Jan 07. - Publication Year :
- 2010
-
Abstract
- Background: Lowered neuropsychological performance is evident in youth with type 1 diabetes, although evidence for associations with specific illness variables is inconsistent. This study examined the neuropsychological profiles of a cohort of youth with type 1 diabetes studied prospectively from diagnosis 12 yr previously.<br />Methods: A total of 106 youth with type 1 diabetes and 75 healthy controls participated. There were no significant group differences on Full-scale IQ assessed on study entry 12 yr previously, current socioeconomic status, gender distribution, or age. Neuropsychological tests assessed eight cognitive domains: verbal abilities, perceptual reasoning, new learning, working memory, non-verbal processing speed, mental efficiency, divided attention, and sustained attention. Episodes of serious hypoglycemia and HbA(1c) levels were recorded from diagnosis.<br />Results: Youth with type 1 diabetes performed more poorly than controls on working memory (p < .05). Early onset diabetes was related to poorer sustained (p < .001) and divided attention (p = .001), new learning, and mental efficiency (both p < .05). Hypoglycemia was found to adversely effect verbal abilities, working memory, and non-verbal processing speed (all p < .05). Poorer working memory was associated with hyperglycemia (p < .05). Youth with any combination of two or three illness risk factors (i.e., early onset diabetes, hypo-, hyperglycemia), performed more poorly than controls and youth with no or one risk on verbal abilities, working memory, and mental efficiency.<br />Conclusions: This study documents poorer neuropsychological performance and its association with illness risk factors in youth with type 1 diabetes. Findings suggest that early disease onset and hypoglycemia impact on the developing central nervous system, with hyperglycemia playing a lesser role.
- Subjects :
- Adolescent
Cohort Studies
Female
Glycated Hemoglobin analysis
Humans
Hyperglycemia psychology
Hypoglycemia psychology
Longitudinal Studies
Male
Neuropsychological Tests
Prospective Studies
Young Adult
Attention
Cognition
Diabetes Mellitus, Type 1 psychology
Memory, Short-Term
Problem Solving
Verbal Learning
Subjects
Details
- Language :
- English
- ISSN :
- 1399-5448
- Volume :
- 11
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pediatric diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 20070555
- Full Text :
- https://doi.org/10.1111/j.1399-5448.2009.00588.x